Which statement about intravenous codeine is true?

Which statement about intravenous codeine is true?

• A. It is well tolerated and commonly used intravenously.
• B. It provides superior antitussive effect intravenously compared to oral form.
• C. Not recommended to give IV due to significant histamine release and associated hypotension.
• D. It has minimal histamine release and rarely causes hypotension.

Answer: (C)

Intravenous codeine is avoided because it frequently triggers histamine release from mast cells, leading to vasodilation and a drop in blood pressure. Giving codeine IV causes rapid peak levels, which can intensify this histamine-mediated hypotension. Since codeine’s analgesic effect depends on metabolism to morphine and its overall efficacy via IV is limited and unpredictable, the risk outweighs any benefit. That’s why the statement stating IV administration is not recommended due to significant histamine release and associated hypotension is true.

Intravenous codeine is avoided because it frequently triggers histamine release from mast cells, leading to vasodilation and a drop in blood pressure. Giving codeine IV causes rapid peak levels, which can intensify this histamine-mediated hypotension. Since codeine’s analgesic effect depends on metabolism to morphine and its overall efficacy via IV is limited and unpredictable, the risk outweighs any benefit. That’s why the statement stating IV administration is not recommended due to significant histamine release and associated hypotension is true.