Remifentanil infusion dose range is:

Remifentanil infusion dose range is:

• A. 0.05-0.25 mcg/kg/min
• B. 1-2 mcg/kg/min
• C. 0.001-0.005 mcg/kg/min
• D. 0.5-1 mcg/kg/min

Answer: (A)

Remifentanil is an ultra-short-acting opioid used for intraoperative analgesia, and its effect ends rapidly after the infusion is stopped because it is quickly metabolized by blood and tissue esterases. Because of this rapid offset, the infusion dose is kept at a modest rate to provide steady analgesia without oversedation, and providers can tighten control by titrating the rate. The commonly used maintenance infusion range is 0.05 to 0.25 mcg/kg/min. This level generally delivers adequate intraoperative analgesia while preserving hemodynamic stability and allowing prompt recovery once the infusion ceases. Starting around 0.1–0.2 mcg/kg/min is common, with adjustments based on patient response. Rates higher than this (for example, 0.5–1 or 1–2 mcg/kg/min) are not typically used as routine maintenance because they increase the likelihood of respiratory depression and other side effects, and very small rates (0.001–0.005 mcg/kg/min) would be insufficient for meaningful analgesia during surgery.

Remifentanil is an ultra-short-acting opioid used for intraoperative analgesia, and its effect ends rapidly after the infusion is stopped because it is quickly metabolized by blood and tissue esterases. Because of this rapid offset, the infusion dose is kept at a modest rate to provide steady analgesia without oversedation, and providers can tighten control by titrating the rate.

The commonly used maintenance infusion range is 0.05 to 0.25 mcg/kg/min. This level generally delivers adequate intraoperative analgesia while preserving hemodynamic stability and allowing prompt recovery once the infusion ceases. Starting around 0.1–0.2 mcg/kg/min is common, with adjustments based on patient response.

Rates higher than this (for example, 0.5–1 or 1–2 mcg/kg/min) are not typically used as routine maintenance because they increase the likelihood of respiratory depression and other side effects, and very small rates (0.001–0.005 mcg/kg/min) would be insufficient for meaningful analgesia during surgery.