Nociceptor mediators include which of the following?

Nociceptor mediators include which of the following?

• A. Substance P
• B. Dopamine
• C. Glucose
• D. Oxygen

Answer: (A)

Nociceptor mediators are chemical signals released during tissue injury that excite or sensitize pain-sensing neurons and amplify inflammatory responses. Substance P is a classic example; it’s released from nociceptive neurons and acts on NK1 receptors to boost pain signaling and to promote vasodilation and plasma leakage, contributing to neurogenic inflammation and hyperalgesia. Dopamine is a central nervous system neurotransmitter mainly involved in reward and modulation of pain processing, but not a primary nociceptor mediator released by injured tissue. Glucose and oxygen are metabolic substrates or gases and do not function as mediators that sensitize nociceptors.

Nociceptor mediators are chemical signals released during tissue injury that excite or sensitize pain-sensing neurons and amplify inflammatory responses. Substance P is a classic example; it’s released from nociceptive neurons and acts on NK1 receptors to boost pain signaling and to promote vasodilation and plasma leakage, contributing to neurogenic inflammation and hyperalgesia. Dopamine is a central nervous system neurotransmitter mainly involved in reward and modulation of pain processing, but not a primary nociceptor mediator released by injured tissue. Glucose and oxygen are metabolic substrates or gases and do not function as mediators that sensitize nociceptors.