Induction dose for fospropofol is which?

Induction dose for fospropofol is which?

• A. 1.5 mg/kg IV
• B. 12 mg/kg IV
• C. 6.5 mg/kg IV
• D. 20 mg/kg IV

Answer: (C)

Fospropofol is a water-soluble prodrug that must be cleaved by alkaline phosphatase to release active propofol. Because not all of the injected fospropofol becomes active propofol at once, a higher dose is needed to achieve the same hypnotic effect as propofol itself. The induction dose used clinically is 6.5 mg/kg IV, which provides the appropriate amount of active propofol after metabolism to induce anesthesia. Doses like 1.5 mg/kg would left insufficient active drug to reach the desired depth, while much higher doses such as 12 or 20 mg/kg increase the risk of airway/respiratory depression and hemodynamic instability.

Fospropofol is a water-soluble prodrug that must be cleaved by alkaline phosphatase to release active propofol. Because not all of the injected fospropofol becomes active propofol at once, a higher dose is needed to achieve the same hypnotic effect as propofol itself. The induction dose used clinically is 6.5 mg/kg IV, which provides the appropriate amount of active propofol after metabolism to induce anesthesia. Doses like 1.5 mg/kg would left insufficient active drug to reach the desired depth, while much higher doses such as 12 or 20 mg/kg increase the risk of airway/respiratory depression and hemodynamic instability.